Black seed oil is being promoted all over the world because of its wide range of healing capabilities.
In 2001 there were 530 citations attributed to nigella sativa. These papers are growing all the time as interest in nigella sativa has grown.
There are 6 seperate patents granted for blackseed.
1) Asthma/allergy therapy using nigella sativa Patent No EP1709995
2)Use of Nigella sativa to increase immune function US Patent No 5482711
3) Herbal composition for diabetes using 23% nigella sativa US Patent No 6042834
4) Use of nigella sativa for inhibition of cancer cell growth US Patent No 5653981
5) For Viral Infections US Patent No 6,841,174
6) For Psoriasis US Patent No 6,531,164
The 530 papers have a rate of citatitions for particular properties. The % shows the interest per subject.
1. Anti-microbial activity /agents 44 8.3% 2. Medicinal properties 40 7.5%
3. Chemical composition 36 6.8% 4. Animal feed 33 6.2%
5. Tissue culture 30 5.7% 6. Plant diseases and their treatment 25 4.7%
7. Plant growth 25 4.7% 8. Anti-cancer activity 22 4.2%
9. Chromosomes 20 3.8% 10. Cropping systems and crop yields 19 3.6%
11. Fatty acids 19 3.6% 12. Mutants 19 3.6 %
13. Seed technology 18 3.4% 14. Toxicity 18 3.4%
15. Anti-oxidantal activity 15 2.8% 16. Fertility / Anti-fertility effect 14 2.6%
17. Metabolism 14 2.6% 18. Oil composition 13 2.5%
19. Thymoquinone 12 2.3% 20. Food chemistry 11 2.1%
21. Hypoglycemic effects 11 2.1% 22. Insecticidal properties 11 2.1%
23. Digestive system diseases 10 1.9% 24. Anti-inflammatory properties 9 1.7%
25. Anti-hypertensive properties 7 1.3% 26. Seed proteins 7 1.3%
27. Anti-asthematic peroperties 6 1.1% 28. Allergic reactions 5 0.9%
29. Anti-viral activity 5 0.9% 30.Cell structure (physical & chemical properties) 5 0.9%
31. Immunologic drug (Human) 4 0.8% 32. Taxanomy 3 0.6%
The Power of Creation
Black cumin seed is certainly created for healing with such a vast amount of healing components packed in a seed. The secret of how it actually works is still not clear. It has been revealed that the components work together in a synergetic effect where they complement each other in the healing process.
Recent research has revealed that blackseed has:-
1. Nutritional value, Black seed is rich in nutritional values.
2. Immune system strengthening
3. Anti-histamine activity
4. Anti-tumor principles
7. Promotes lactation
8. Monosaccharides (single molecule sugars) in the form of glucose, rhamnose, xylose, and arabinose are found in the black seed. The black seed contains a non-starch polysaccharide component which is a useful source of dietary fiber.
The Key of Creation
Hair of the Holy Prophet (SWS)
Black seed is the key to good health. As mentioned by the Holy Prophet (SWS) "Hold on to the use of the black seed for indeed it has a remedy for all disease except death."
Recent research has certainly verified his saying where black seed has been shown to be powerful enough to use at a practitioners level with astounding vesatility for severe illnesses. At the same time it is safe enough to be used at the home for a vast array of ailments.
1. Immune system strengthening
Studies begun just over a decade ago suggest that if used on an ongoing basis, black seed can play an important role to enhance human immunity, particularly in immuno-compromised patients.
In 1959, the active ingredient in black seed, crystalline Nigellone, was first isolated and identified as providing many health benefits. Clinical trials have validated the efficacy of black seed in promoting health and wellness.
In 1986, Drs. El-Kadi and Kandil conducted a study with human volunteers to test the efficiency of black seed as a natural immune enhancer.
The first group of volunteers received black seed capsules (1 gram twice daily) for four weeks and the second group were given a placebo. A complete lymphocyte count carried out in all volunteers before and four weeks after administration of black seed and the placebo revealed that the majority of subjects who took black seed displayed a 72% increase in helper to suppresser T-cells ratio, as well as an increase in natural killer cell functional activity. The control group who received the placebo experienced a net decline in ratio of 7%. They reported, "These findings may be of great practical significance since a natural immune enhancer like the black seed could play an important role in the treatment of cancer, AIDS, and other disease conditions associated with immune deficiency states."
These results were confirmed by a study published in the Saudi Pharmaceutical Journal in 1993 by Dr. Basil Ali and his colleagues from the College of Medicine at Kin Faisal University.
In the field of AIDS research specifically, tests carried out by Dr. Haq on human volunteers at the Department of Biological and Medical Research Center in Riyadh, Saudi Arabia (1997) showed that black seed enhanced the ratio between helper T-cells and suppresser T-cells by 55% with a 30% average enhancement of the natural killer (NK) cell activity.
2. Anti-histamine activity
Histamine is a substance released by bodily tissues, sometimes creating allergic reactions and is associated with conditions such as bronchial asthma.
In 1960, scientists Badr-El-Din and Mahfouz found that dimer dithymoquinone isolated from black seed's volatile oil, under the name of "Nigellone," and given by mouth to some patients suffering from bronchial asthma, suppressed the symptoms of the condition in the
majority of patients.
Following the results of this early study, crystalline nigellone was administered to children and adults in the treatment of bronchial asthma with effective results and no sign of toxicity. It was observed, however, that although effective, crystalline nigellone displayed a delayed reaction.
In 1993, Nirmal Chakravarty, M.D., conducted a study to see if this delay could be attributed to the possibility of crystalline nigellone being an inhibitory agent on histamine. His hypothesis proved correct. Dr. Chakravarti's study found that the actual mechanism behind the suppressive effect of crystalline nigellone on histamine is that crystalline nigellone inhibits protein kinase C, a substance known to trigger the release of histamine. In addition, his study showed that crystalline nigellone decreased the uptake of calcium in mast cells, which also inhibits histamine release.
The importance of these results are that people who suffer from bronchial asthma and other allergic diseases may benefit from taking crystalline nigellone.
3. Anti-tumor principles
A study of black seed's potential anti-tumor principles by the Amala Research Center in Amala Nagar, Kerala (India) in 1991 lent further impetus to Dr. Chakravarty's suggestion for the possible use of black seed in the treatment of cancer.
Using an active principle of fatty acids derived from black seed, studies with Swiss albino mice showed that this active principle could completely inhibit the development of a common type of cancer cells called Ehrlich ascites carcinoma (EAC). A second common type of cancer cells, Dalton's lymphoma ascites (DLA) cells were also used.
Mice which had received the EAC cells and black seed remained normal without any tumor formation, illustrating that the active principle was 100% effective in preventing EAC tumor development. Results in mice who received DLA cells and black seed showed that the active principle had inhibited tumor development by 50% less compared to mice not given the active principle.
The study concluded, "It is evident that the active principle isolated from nigella sativa seeds is a potent anti-tumor agent, and the constituent long chain fatty acid may be the main active component."
Anti-angiogenic activity of nigella sativa plant extract in cancer therapy
AUTHOR: Medenica R, Janssens J, Tarasenko A, Lazovic G, Corbitt W, Powell D, Jocic D, Mujovic
ADDRESS: International Immuno-Biology Research Laboratory, South Carolina, 29926
SOURCE: Proc Annu Meet Am Assoc Cancer Res; 38:A1377 1997
ABSTRACT: Nigella sativa [NS], or 'black cumin', an annual herb belonging to the family Ranunculaceae, has strong immunomodulatory and interferon-like activity. We confirm that our extract of NS inhibits cancer and endothelial cell progression, decreases the production of the angiogenic protein-fibroblastic growth factor (FGF) made by tumor cells, and inhibits growth factor for endothelial cells. FGF-1 and FGF-2 are both localized to myoepithelial and to epithelial cells.
FGF is an autocrine growth factor developed in our immortalized human mammary epithelial cells. FGF-2, present in aggressive breast cancer, was suppressed by NS. In addition, our breast cancer cell line contains FGF 1-4. Tumor growth is angiogenesis dependent and neo-vascularization is a crucial determinant of the metastatic potential of the tumor. Formed vessels in tumors are hyper-permeable to plasma protein, due to gaps in the endothelial lining. These vascular abnormalities could facilitate entry of the tumor cells into the circulation.
We studied breast cancer, prostate cancer and melanoma cells for acidic fibroblast growth factor which we isolated and suppressed by NS. We attempted to recapitulate early angiogenic evidence in vitro by developing a model of endothelial growth migration and extra cellular matrix interaction. Our in vitro assay revealed that stimulated endothelial cells can produce degradative proteinase and invade the extracellular matrix similarly to tumor cells. Moreover, this model system indicated that a fine tuned balance between proteinase and proteinase inhibitor regulates vascular morphogenesis and invasion. Migrating endothelial cells produce Type 4 collagenase (member of the matrix metalloproteinase family) and serineproteinase. We demonstrated that specific inhibitors of Type 4 collagenase, general metalloproteinase inhibitors and serineproteinase inhibitors blocked endothelial cell invasion of the extra cellular matrix. These inhibitors blocked tumor cell invasion in the same assay. NS was compared with these factors and shown to have the same action. The endothelial cells in culture were reverted to a non-angiogenic state when the angiogenic stimulus is neutralized by NS.
Conclusion: The activity of NS blocked the tumor growth and dissemination in metastasis and have remarkable promises for clinical use.
In 1989, a report appeared in the Pakistan Journal of Pharmacy about anti-fungal properties of the volatile oil of black seed. 1992 saw researchers at the Department of Pharmacy, University of Dhaka, Bangladesh, conducting a study in which the antibacterial activity of
the volatile oil of black seed was compared with five antibiotics: ampicillin, tetracycline, cotrimoxazole, gentamicin, and nalidixic acid.
The oil proved to be more effective against many strains of bacteria, including those known to be highly resistant to drugs: V. cholera, E. coli (a common infectious agent found in undercooked meats), and all strains of Shigella spp., except Shigella dysentriae. Most strains of Shigella have been shown to rapidly become resistant to commonly used antibiotics and chemotheraputic agents.
In light of the above research findings, it is of interest that homeopaths have long been known to make a tincture from the black seed for digestive and bowel complaints. Traditionally, the black seed is still used to help relieve vomiting and diarrhea, as well as flatulent colic, and to help counteract the griping action of purgatives (e.g. certain laxatives, fruits such as apricots when over consumed).
As early as 1960, Professor El-Dakhakny reported that black seed oil has an anti-inflammatory effect and that it could be useful for relieving the effects of arthritis. In 1995, a group of scientists at the Pharmacology Research Laboratories, Department of Pharmacy, Kings College, London, decided to test the effectiveness of the fixed oil of Nigella sativa and its derivative, thymoquinine, as an anti-inflammatory agent. Their study found that the oil inhibited eicosanoid generation and demonstrated anti-oxidant activity in cells. The inhibition of eicasanoid generation, however, was higher than could be expected from thymoquinone alone.
Their study suggested that other compounds within the oil might also be responsible for the enhanced anti-inflammatory reactions in cells. The scientists speculated that the unusual C20:2 unsaturated fatty acids contained in black seed were possibly responsible for
boosting the oil's effectiveness.
In 1997, studies conducted at the Microbiological Unit of the Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, found that externally in an ointment form, the anti-inflammatory activity of the black seed was found to be in the same range as that of other similar commercial products. The tests also demonstrated that the black seed is
6. Promotes lactation
A study by Agarwhal (1979) showed that black seed oil increases the milk output of breastfeeding mothers. A literature search by the University of Potchefstroom (1989), including biological abstracts, revealed that black seed's capacity to increase the milk flow of nursing mothers could be attributed to a combination of lipid portion and hormonal structures found in the black seed.